Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
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Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
Accumulating evidence indicates that senescent cells play an important role in many age-associated diseases. The pharmacological depletion of senescent cells (SCs) with a "senolytic agent", a small molecule that selectively kills SCs, is a potential novel therapeutic approach for these diseases. Recently, we discovered ABT-263, a potent and highly selective senolytic agent, by screening a libra...
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ژورنال
عنوان ژورنال: Aging
سال: 2016
ISSN: 1945-4589
DOI: 10.18632/aging.101100